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A core pathogenic mechanism involves A oligomers embedding into the lipid bilayer of cell membranes, disrupting the spatial conformation of phospholipid dehydrogenases

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In addition, improved antioxidant balance can support clearer-looking skin over time

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Niacinamide: Also known as vitamin B3, niacinamide can help regulate melanin production and improve overall skin texture

To enhance sensitivity, specificity, and translational relevance, future research should incorporate multimodal biomarker strategiescombining imaging, fluid-based, and multi-omics analyses